Does hormonal response to clomiphene citrate differ for morbidly obese men?

Clomiphene Citrate Effectively Increases Testosterone in Obese, Young, Hypogonadal Men.

BACKGROUND Obesity has been associated with low testosterone (T) in adult males and in pubertal boys. Therapy for hypogonadism with exogenous T may lead to testicular atrophy and later infertility. Only a few studies have demonstrated that the Selective Estrogen Receptor Modulator (SERM) clomiphene citrate (CC), an estrogen receptor antagonist, increases T in obese hypogonadal men while prevent...

The treatment of subfertile men with clomiphene citrate.

In a double-blind clinical trial, 114 subfertile men were given courses of clomiphene citrate (100 mg daily for three 10-day periods in successive months) and ofplacebo tablets of identical appearance. There were no consistent changes in sperm density. No serious adverse reactions to clomiphene were seen. Further studies are recommended on the efficacy of clomiphene in doses of 25 to 50 mg dail...

Does Adding Dexamethasone to Clomiphene Citrate Improve Ovulation in PCOS Patients? A Triple - Blind Randomized Clinical Trial Study

CLOMID® (clomiphene citrate tablets USP)

Clomiphene citrate is a white to pale yellow, essentially odorless, crystalline powder. It is freely soluble in methanol; soluble in ethanol; slightly soluble in acetone, water, and chloroform; and insoluble in ether. CLOMID is a mixture of two geometric isomers [cis (zuclomiphene) and trans (enclomiphene)] containing between 30% and 50% of the cis-isomer. Each white scored tablet contains 50 m...

Clomiphene Citrate and Oocyte Quality

Ovary is a dynamic organ and generates excess amount of reactive oxygen species (ROS) during follicular growth, development, maturation and ovulation [1]. The increased level of ROS is scavenged by antioxidant systems [2]. A moderate increase of ROS could be beneficial for oocyte meiotic maturation and reproductive outcome [3-5]. Overproduction of ROS or depletion of enzymatic antioxidant syste...